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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490848Generated: October 30, 2026

2-Methyl-2,3-dihydro-1H-isoindol-1-one → 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

https://huagongshe.com/reaction/1490848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2,3-dihydro-1H-isoindol-1-oneHCID 220657—
ReagentBis(pinacolato)diboraneHCID 2733548—
Reagent4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventP-XyleneHCID 7809—
Product2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-oneHCID 4685641628%
Product2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-oneHCID 5769122426%

Reaction Conditions

Temperature35 °C

Provenance & Evidence

DOI10.1038/nchem.2322
Source datasetBorylation dataset from Roche
ORD IDord-4d9439b94bfa4113b4442f24c09c900d
Source noteBorylation dataset from Roche