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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490880Generated: October 30, 2026

N,N-Dimethyl 2-pyridinecarboxamide → N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)picolinamide

https://huagongshe.com/reaction/1490880

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,N-Dimethyl 2-pyridinecarboxamideHCID 12272694—
ReagentBis(pinacolato)diboraneHCID 2733548—
Reagent4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventP-XyleneHCID 7809—
ProductN,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)picolinamideHCID 4976050658%
ProductN,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamideHCID 5741649130%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/nchem.2322
Source datasetBorylation dataset from Roche
ORD IDord-c18f3dd0c2f745d092d4ad27e5b67fd8
Source noteBorylation dataset from Roche