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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490883Generated: October 30, 2026

Ethyl 2-pyridylacetate → Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetate

https://huagongshe.com/reaction/1490883

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-pyridylacetateHCID 75960—
ReagentBis(pinacolato)diboraneHCID 2733548—
Reagent1-(2-([2,2'-Bipyridin]-5-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)ureaHCID 91820781—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventP-XyleneHCID 7809—
ProductEthyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetateHCID 9182077759%
ProductEthyl 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetateHCID 13011587140%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/nchem.2322
Source datasetBorylation dataset from Roche
ORD IDord-af90c5df9b774d419b8d66d2861e668c
Source noteBorylation dataset from Roche