HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490903Generated: October 30, 2026
4-Chloro-7-(trifluoromethyl)quinoline → HCID 178431096, compound
https://huagongshe.com/reaction/1490903
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 178431096 | HCID 178431096 | 81% |
Reaction Steps
General procedure A was applied to 4-chloro-7-(trifluoromethyl)quinoline (231 mg, 1.00mmol). Purification by recrystallisation from acetonitrile, afforded 4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-7-(trifluormethyl)quinoline as a white solid (289 mg, 81%); m.p.93 -94 °C;
Provenance & Evidence
| DOI | 10.1039/c2sc20776a |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-7a17fdd932c54be285708fd64e8dcd7b |
|---|
| Source note | Borylation dataset from Roche |
|---|
