HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490906Generated: October 30, 2026
6-Methoxyquinaldine → HCID 178487840, compound
https://huagongshe.com/reaction/1490906
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-Methoxyquinaldine | HCID 70648 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 178487840 | HCID 178487840 | 76% |
Reaction Steps
General procedure A was applied to 2-methyl-6-methoxyquinoline (173 mg, 1.00mmol). Purification by silica gel flash-columnchromatography with gradient elution of MeOH/DCM from 0.5 -12.5% over 25 column volumes, affording 6-methoxy-2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2-dioxaborolan-2-yl)quinolineas an off-white solid (227 mg, 76%);
Provenance & Evidence
| DOI | 10.1039/c2sc20776a |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-eed55d2d7131490b8e23983840915e3e |
|---|
| Source note | Borylation dataset from Roche |
|---|
