7-Methoxy-2-methylquinoline → HCID 178486990, compound

Participants

Reaction Conditions

Reaction Steps

General procedure B was applied to 7-methoxy-2-methylquinoline (173 mg, 1.00mmol). The reaction was stirred at room temperature for 48 hours affording a 95:5 mixture of 2 monoborylated products as determined by GC-MS. Volatiles were removed under reduced pressure and the remaining residue was purified by silica gel flash-column chromatography with gradient elution of MeOH/DCM from 0.5 -12.5% over 25 column volumes, affording the major 7-methoxy-2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)quinolineproduct as a pale yellow solid (218 mg, 73%); m.p.87 -88 °C;

Provenance & Evidence