HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490927Generated: October 30, 2026
Methyl 2-Methoxybenzoate → Methyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
https://huagongshe.com/reaction/1490927
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 2-Methoxybenzoate | HCID 61151 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Methyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 22171502 | 85% |
| Product | Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 22930502 | 15% |
Reaction Steps
General procedure Cwas applied to methyl 2-methoxybenzoate15c(66mg, 0.4mmol). The reaction mixture was stirredat room temperature for 16hours giving a conversion of >99% (GC-MS) and 16cand 17cin a 85:15mixture(1H NMR spectrum).
Provenance & Evidence
| DOI | 10.1039/c2sc20776a |
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| Source dataset | Borylation dataset from Roche |
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| ORD ID | ord-4f8c6610445e45ab8ee87e5582f3798b |
|---|
| Source note | Borylation dataset from Roche |
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