HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490928Generated: October 30, 2026
2'-Methoxyacetophenone → 1-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone
https://huagongshe.com/reaction/1490928
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2'-Methoxyacetophenone | HCID 68481 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 1-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone | HCID 58629863 | 89% |
| Product | HCID 129984304 | HCID 129984304 | 11% |
Reaction Steps
General procedure Cwas applied to 1-(2-methoxyphenyl)ethanone15d(60mg, 0.4mmol). The reaction mixture was stirredat room temperature for 16hours giving a conversion of >99% (GC-MS) and 16dand 17din a 89:11mixture(1H NMR spectrum)and some unreacted starting material 15d.
Provenance & Evidence
| DOI | 10.1039/c2sc20776a |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-c42ab34778ba41929035b71d38ce5430 |
|---|
| Source note | Borylation dataset from Roche |
|---|
