HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490930Generated: October 30, 2026
2-Methylacetophenone → 1-[2-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone
https://huagongshe.com/reaction/1490930
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylacetophenone | HCID 11340 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 1-[2-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone | HCID 75487196 | 49% |
| Product | 1-[2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone | HCID 129946646 | 38% |
Reaction Steps
General procedure Cwas applied to 1-(2’-methylphenyl)ethanone15f(54mg, 0.4mmol). The reaction mixture was was stirredat room temperature for 16hours giving a conversion of 87%(GC-MS) and 16fand 17fin a 56:44 mixture which also contained unreacted starting material 15f(1H NMRspectrum).
Provenance & Evidence
| DOI | 10.1039/c2sc20776a |
|---|
| Source dataset | Borylation dataset from Roche |
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| ORD ID | ord-7774858fb93f41f7b91cc112210ae5ae |
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| Source note | Borylation dataset from Roche |
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