HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490972Generated: October 29, 2026
HCID 178457674, compound → HCID 178457670, compound
https://huagongshe.com/reaction/1490972
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 178457674 | HCID 178457674 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 8-([2,2'-bipyridin]-5-yl)quinolin-2(1H)-one | HCID 164681385 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Catalyst | Potassium tert-butoxide | HCID 86639980 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178457670 | HCID 178457670 | 20% |
Reaction Steps
In an argon filled glove box, a 5.0 mL weaton microreactor was charged with [Ir(cod)(OMe)]2 (1.98 mg, 1.5 mol%), L1 ligand (2.1 mg, 3.5 mol%), B2pin2 (50.8 mg, 1.0 equiv.), KOtBu (1.0 mg, 4.5 mol%) and dry THF (1.0 mL). The reaction mixture was stirred for 2 minutes at room temperature. To this mixture, N,N-diisopropyl-1-methyl-1H-indole-7-carboxamide (51.7 mg, 0.2 mmol) was added. The microreactor was capped with a teflon pressure cap and placed into preheated aluminum block at 80 oC. After 12 h, the crude reaction mixture was analyzed (conversion was 20% and rapid protodeborylation occurred, thus failed to isolate).
Provenance & Evidence
| DOI | 10.1002/anie.201809929 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-6afcb8a5395f45259183ab9b66a9b88a |
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| Source note | Borylation dataset from Roche |
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