HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pivaloylpiperidine → 2,2-Dimethyl-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl]propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pivaloylpiperidine | HCID 4418119 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Methyl-1,10-phenanthroline | HCID 4913356 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | Cyclooctane | HCID 9266 | — |
| Product | 2,2-Dimethyl-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl]propan-1-one | HCID 177572362 | 42% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Provenance & Evidence
| DOI | 10.1126/science.aba6146 |
|---|---|
| Source dataset | Borylation dataset from Roche |
| ORD ID | ord-344577d67a254196a272f351ece01687 |
| Source note | Borylation dataset from Roche |