HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491130Generated: October 26, 2026
(Ethylthio)benzene → 2-(2-(Ethylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491130
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Ethylthio)benzene | HCID 12144 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | 2-(2-(Ethylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 123787969 | 72% |
Reaction Steps
Ligand 3f: The mixture of product (95 mg, 72% yield, ortho/meta + para = >30); ortho-borylated product 4b was obtained by further purification of the crude mixture by GPC (89 mg, 67% yield), white solid (mp. 48-50 oC)
Provenance & Evidence
| DOI | 10.1002/anie.201610041 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-b26c7059a55f4ed08e56318eb7eb563c |
|---|
| Source note | Borylation dataset from Roche |
|---|
