化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1491134作成日：2026年10月26日
Benzene, 1-methyl-4-(methylthio)- → 4,4,5,5-Tetramethyl-2-(5-methyl-2-(methylthio)phenyl)-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491134
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzene, 1-methyl-4-(methylthio)- | HCID 69334 | — |
| 試薬 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 試薬 | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| 触媒 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 溶媒 | P-Xylene | HCID 7809 | — |
| 生成物 | 4,4,5,5-Tetramethyl-2-(5-methyl-2-(methylthio)phenyl)-1,3,2-dioxaborolane | HCID 138983642 | 73% |
反応手順
Ligand 3f: A mixture of ortho- and meta-borylated products (96 mg, 73% yield, ortho/meta + para = >30); ortho-borylated product 4d was obtained by further purification by GPC (74 mg, 56% yield), white solid (mp. 85-87 oC)
情報源と証拠
| DOI | 10.1002/anie.201610041 |
|---|
| 出典データセット | Borylation dataset from Roche |
|---|
| ORD ID | ord-eda2f8caaac94e09ad4fd261444e08c6 |
|---|
| 出典メモ | Borylation dataset from Roche |
|---|
