HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1491136Erstellt: 25. Oktober 2026
1-Chloro-4-(methylthio)benzene → 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491136
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Chloro-4-(methylthio)benzene | HCID 31243 | — |
| Reagenz | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagenz | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| Katalysator | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Lösungsmittel | P-Xylene | HCID 7809 | — |
| Produkt | 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 163198006 | 74% |
| Produkt | HCID 178503174 | HCID 178503174 | 6% |
Reaktionsschritte
Ligand 3f: A mixture of ortho- and meta-borylated products (114 mg, 80% yield, ortho/meta + para = 12); ortho-borylated product 4e was obtained by further purification by GPC (70 mg, 49% yield), white solid (mp. 80-82 oC);
Herkunft & Nachweise
| DOI | 10.1002/anie.201610041 |
|---|
| Quelldatensatz | Borylation dataset from Roche |
|---|
| ORD ID | ord-903f8118d14f42ecaa64e874e6518ce2 |
|---|
| Quellennotiz | Borylation dataset from Roche |
|---|
