HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491158Generated: October 26, 2026
Methyl 3-(methylthio)benzoate → Methyl 3-methylsulfanyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
https://huagongshe.com/reaction/1491158
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 3-(methylthio)benzoate | HCID 6432769 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | Methyl 3-methylsulfanyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 138983103 | 89% |
Reaction Steps
Ligand 3f: A mixture of ortho- and meta-borylated products (137 mg, 89% yield, ortho/meta + para = >30); ortho-borylated product 4p was obtained by further purification by GPC (130 mg, 84% yield), colorless oil;
Provenance & Evidence
| DOI | 10.1002/anie.201610041 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-1ca446d9d6814fc6a92bb8beb0f40517 |
|---|
| Source note | Borylation dataset from Roche |
|---|
