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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491466Generated: November 1, 2026

4-Bromo-2-fluorobenzonitrile → 4-Bromo-2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

https://huagongshe.com/reaction/1491466

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-fluorobenzonitrileHCID 736029—
Reagent4,4,5,5-Tetramethyl[1,3,2]dioxaborolaneHCID 2734768—
Reagent4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventTetrahydrofuranHCID 8028—
Product4-Bromo-2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 5342663981%
Product4-Bromo-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 1299765514%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja0428309
Source datasetBorylation dataset from Roche
ORD IDord-5e7f3eae47f147d3b723e00940fd0e6d
Source noteBorylation dataset from Roche