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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491469Generated: October 31, 2026

5-Bromopyridine-2-carbonitrile → 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile

https://huagongshe.com/reaction/1491469

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromopyridine-2-carbonitrileHCID 817154—
Reagent4,4,5,5-Tetramethyl[1,3,2]dioxaborolaneHCID 2734768—
Reagent4,4'-Di-tert-butyl-2,2'-bipyridylHCID 4249187—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventTetrahydrofuranHCID 8028—
Product5-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrileHCID 4976047629%
Product5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrileHCID 7130367852%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja0428309
Source datasetBorylation dataset from Roche
ORD IDord-df50bffb88a24ca692339016f6e8a2c2
Source noteBorylation dataset from Roche