HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491494Generated: October 26, 2026
1-(2-Methoxyphenyl)isoquinoline → 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline
https://huagongshe.com/reaction/1491494
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-Methoxyphenyl)isoquinoline | HCID 23159734 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 4,4,5,5-Tetramethyl[1,3,2]dioxaborolane | HCID 2734768 | — |
| Reagent | N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine | HCID 67601456 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline | HCID 101547938 | 88% |
Reaction Steps
Following the general procedure, precipitation from the reaction crude with hexane and trituration afforded 9i (159 mg, 88 %) as a pale solid.
Provenance & Evidence
| DOI | 10.1002/anie.201104544 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-2dd73b1c305947e1a593c90545f7d2d2 |
|---|
| Source note | Borylation dataset from Roche |
|---|
