Tert-Butylbenzene → 2-Methoxy-2-oxoethyl lactate

Participants

Reaction Steps

A 6.5 mL aliquot of an ethyl ether solution containing 0.25M 2-chloroethyl lactate (prepared as described in Example 1a), 0.25M methyl glycolate, and 0.125% tert-butylbenzene was added to 0.5 g Lipase P30. After mixing for 48 hr at room temperature, the conversion of 2-chloroethyl lactate to the title compound was estimated (by GC, Method A) to be 40%. In identical reactions substituting Lipase AK, Lipase G, Lipase MAP10, Protease M, Lipase AP12, or porcine pancreatic lipase for Lipase P30, the relative values for conversions at 48 hr (Lipase P30=100) were 101, 90, 44, 43, 32, and 13, respectively.

Provenance & Evidence