Isopropyl hydroxyacetate → 2-(1-Methylethoxy)-2-oxoethyl lactate

Participants

Reaction Steps

The efficacy of various enzyme preparations to catalyze the conversion of 0.25M 2-chloroethyl lactate and 0.25M isopropyl glycolate in ethyl ether to the title compound was determined after reaction for 24 hr with 0.5 g enzyme per 6.5 mL reaction mixture. Substituting Lipase AK, porcine pancreatic lipase, Lipase MAP10, Protease M, Lipase AP12, or Lipase G for Lipase P30, the relative values for conversion (Lipase P30=100) were 104, 44, 40, 36, 29 and 26, respectively. In each case substitution of acetonitrile for ethyl ether resulted in a slight reduction in the rate of reaction.

Provenance & Evidence