2-Chloroethanol → HCID 18953229, compound

HRID 1491537Notes

Reaction equation

HRID 1491537 reaction equation
[OH:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].[Cl:8][CH2:9][CH2:10]O>>[OH:1][C:2]([CH3:7])([CH3:6])[C:3]([O:5][CH2:10][CH2:9][Cl:8])=[O:4]

Participants

3

Reactant 2

HCID 342-ChloroethanolHCID 116712-Hydroxyisobutyric acid

Product 1

HCID 18953229HCID 18953229, compound

Procedure

2-Chloroethyl 2-hydroxy-2-methylpropionate was prepared from 2-hydroxy-2-methylpropionic acid and excess 2-chloroethanol essentially by the method described in Step 1 of Example 1: b.p. 75°-77° C./6 mm Hg; 1H NMR δ1.47 (s, 6H), δ3.18 (s, 1H), δ3.72 (t, 2H, J= 5.6 Hz), δ4.43 (t, 2H, J=5.6 Hz); 13C NMR 27.1, 41.2, 64.8, 72.1, 176.8 ppm; HRMS calcd for C5H7ClO3Tms (M-CH3) 223.0557, obsd 223.0577.

Sources & evidence

ORD record
ord-cb079f5c3e7e4299ba6a83c00bfa2e21
Source dataset
uspto-grants-1994_12
Patent number
US05371001

Reaction notes

Loading…