Diethyl Ether → HCID 53961620, compound

Participants

Reaction Steps

2-Chloroethyl 2-hydroxy-2-methylpropionate, prepared as described in Step 1 of Example 3a, (5.22 g, 31.3 mmol) and methyl glycolate (2.83 g, 31.4 mmol) in 125 mL of ethyl ether containing 0.125% tert-butylbenzene was added to 9.0 g Lipase P30 and the reaction mixture was agitated on an orbital shaker for 4d. The enzyme powder was removed by filtration, the solvent was removed, and a portion of the resulting residue was purified by flash chromatography (ethyl acetate:hexane, 20/80) to give the title compound as an oil: 1H NMR δ1.51 (s, 6H), δ3.14 (s, 1H), δ3.78 (s, 3H), δ4.71 (s, 2H); 13C NMR 27.0, 52.1, 61.1, 72.1, 167.6, 176.4 ppm.

Provenance & Evidence