2-Chloroethanol → HCID 18953225, compound

Participants

Reaction Steps

2-Chloroethyl 2-hydroxy-3-methylbutyrate was prepared from 2-hydroxy-3-methylbutyric acid and excess 2-chloroethanol essentially by the method described in Step 1 of Example 1: b.p. 137° C./20 mm Hg; 1H NMR δ0.90 (d, 3H, J=6.9 Hz), δ1.04 (d, 3H, J=6.9 Hz), δ2.12 (dqq, 1H, J=3.6, 6.9, 6.9 Hz), δ2.76 (d, 1H, J=6.4 Hz), δ3.72 (t, 2H, J=5.6 Hz), δ4.10 (dd, 1H, J=3.6 Hz, 6.3 Hz), δ4.36-4.53 (m, 2H); HRMS calcd for C6H9ClO3Tms (M-CH3) 237.0714, obsd 237.0677.

Provenance & Evidence