Tert-Butylbenzene → HCID 54181210, compound

Participants

Reaction Steps

A 6 mL aliquot of an ethyl ether solution containing 0.25M 2-chloroethyl 2-hydroxy-3-methylbutyrate, 0.25M methyl glycolate, and 1.0% tert-butylbenzene was added to 0.40 g Lipase P30. After mixing for 10 d at room temperature, the conversion of 2-chloroethyl 2-hydroxy-3-methylbutyrate to the title compound was estimated (by GC, Method A) to be <20%. The GC peak assigned to the title compound was confirmed by HRMS: calcd for C7H10O5Tms (M-CH3) 247.1001, obsd 247.0973. In identical reactions substituting Lipase AK or porcine pancreatic lipase for Lipase P30, the relative values for conversions at 10 d (Lipase P30=100) were 33 and 0, respectively.

Provenance & Evidence