Ethyl orthoformate → HCID 53795986, compound

Participants

Reaction Steps

A mixture of 1-[2-chloro-4-(methylsulphonyloxy)phenyl]-3-cyclopropylpropan-1.3-dione (4.75 g) and triethyl orthoformate (4.5 g) in acetic anhydride was stirred and heated at reflux for 3 hours. The mixture was cooled and evaporated to dryness. Toluene was added and the mixture as re-evaporated to give 1-[2-chloro-4-(methylsulphonyloxy)phenyI]-3-cyclopropyl-2-ethoxymethylenepropan-1,3-dione (5.7 g) as a brown oil which was not further purified.

Provenance & Evidence