Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) → HCID 67820322, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.93 g (7.5 mmol) of 2-(3-ethoxycarbonyl-propoxy)-6-(4,6-dimethoxy-pyrimidin-2-yl-oxy)-benzaldehyde (cf. Example 1), 1.5 g (8.3 mmol) of 4-chloro-phenylhydrazine-hydrochloride, 0.76 g(9.3 mmol) of sodium acetate and 150 ml of methylene chloride is stirred at 20° C. for 15 hours, then washed with saturated disodium hydrogen phosphate solution, dried with sodium sulphate and filtered. The filtrate is concentrated, the residue is stirred with methanol and the crystalline product is isolated by filtering off with suction. 2.6 g (67% of theory) of 2-(3-ethoxycarbonyl-propoxy)-6-(4,6-dimethoxy-pyrimidin-2-yl-oxy)-benzaldehyde-4-chloro-phenylhydrazone of melting point 139° C. are obtained.

Provenance & Evidence