m-Chloroperbenzoic acid → HCID 18953292, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-cyclopropyl-4-[2-(4-chlorophenylsulphenyl)-4-trifluoromethylbenzoyl]isoxazole (1.14 g) and 3-chloroperoxybenzoic acid (0.84 g) in dichloromethane was stirred at -12° C. for 15 minutes. The precipitate was filtered and the filtrate was washed with aqueous sodium metabisulphite, aqueous sodium bicarbonate and a solution of brine and ammonium chloride, dried over anhydrous sodium sulphate and filtered. The dichloromethane was evaporated and the residue was crystallised from ethanol to give 5-cyclopropyl-4-[2-(4-chlorophenylsulphinyl)-4-trifluoromethylbenzoyl]isoxazole (compound 9, 0.86 g) as white crystals, m.p. 151° C.

Provenance & Evidence