Ethyl orthoformate → HCID 54075857, compound

HRID 1491572Notes

Reaction equation

HRID 1491572 reaction equation
[CH:1]1([C:4](=[O:26])[CH2:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[S:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[O:7])[CH2:3][CH2:2]1.[CH2:27]([O:29][CH:30](OCC)OCC)[CH3:28]>C(OC(=O)C)(=O)C>[CH:1]1([C:4](=[O:26])[C:5](=[CH:30][O:29][CH2:27][CH3:28])[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:10][C:9]=2[S:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 18953317HCID 18953317, compound

Product 1

HCID 54075857HCID 54075857, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of 3-cyclopropyl-1-[2-(4-chlorophenylsulphenyl)-4-trifluoromethylphenyl]propan-1,3-dione (2.9 g) and triethylorthoformate (2.3 g) in acetic anhydride (2.4 g) was heated at reflux for 75 minutes. The reaction mixture was concentrated to give 3-cyclopropyl- 1-[2-(4-chlorophenylsulphenyl)-4-trifluoromethylphenyl]-2-ethoxymethylenepropan-1,3-dione as a red oil which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 75 minutes
  3. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-2d703a5618f7497cac135942264ccfdb
Source dataset
uspto-grants-1994_12
Patent number
US05371064

Reaction notes

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