HCID 18953493, compound → HCID 18953530, compound

Participants

Reaction Steps

To a stirred solution of 2-chloro-4-morpholino-5-trifluoromethyl-quinazoline (600 mg, 1.9 mmol) and 3-cyclopropyl-5-isocyanomethyl-1,2,4-oxadiazole (440 mg, 2.9 mmol) in dry DMF (15 ml) under nitrogen at 5°-10° C. was added solid potassium t-butoxide (330 mg, 2.9 mmol). The mixture was stirred at 5°-10° C. for 0.5 h and triturated with water (20 ml). The crystals were filtered off and washed with water (10 ml) and ethyl acetate. A final purification was done by stirring the crystals in acetone (10 ml) to give 330 mg of the title compounds, m.p. 197°-199° C.

Provenance & Evidence