Acetic Acid → HCID 18953411, compound

Participants

Reaction Steps

A mixture of ethyl 7-fluoro-5-morpholino-imidazo[1,5-a]quinazoline-3-carboxylate (1.6 g), 2-methyl-1-propanecarboxamide oxime (2.4 g), crushed 4 Å molecular sieves (3.5 g), and sodium hydride (0.14 g, 80% in mineral oil) in 20 ml of dry DMF was stirred at ambient temperature. After 1 hour an additional amount of the carboxamide oxime (2.4 g) and sodium hydride suspension (0.14 g) was added, and the mixture was stirred for one more hour. Glacial acetic acid (2 ml) and dichloromethane (50 ml) were added, and after the precipitated product had dissolved the sieves were removed by filtration through celite. The filtrate was evaporated and the residue was triturated with 100 ml of water. The undissolved material was collected by filtration, dried and treated with 25 ml of acetone. Yellow crystals precipitated and were filtered off and dried. Yield 0.47 g, m.p. 262°-264° C.

Provenance & Evidence