Acetic Acid → HCID 18953495, compound

Participants

Reaction Steps

A solution of potassium t-butoxide (2.1 g, 19 mmol) in dry DMF (15 ml) was added during 15 min. at 0°-5° C. to a stirred solution of 2-chloro-4-morpholino-quinazoline (3.0 g, 12 mmol) and ethyl isocyanoacetate (2.1 g, 19 mmol) in dry DMF (40 ml). The mixture was stirred at room temperature for 2 hours. Then glacial acetic acid (2 ml) was added and the solvent was evaporated in vacuo. The residue was triturated with a mixture of water (50 ml) and ethyl acetate (10 ml) giving the title compound as a pale yellow precipitate. The product was collected by filtration and rinsed with water and ethyl acetate and dried. Yield 3.6 g (91%), m.p. approx. 165° C., resolidifies to give crystals melting at 195.5°-196.5° C.

Provenance & Evidence