n-Methyl-3-nitropyridin-4-amine → 4-N-methylpyridine-3,4-diamine

HRID 1491634Notes

Reaction equation

HRID 1491634 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH:10][CH3:11])([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH:10][CH3:11]

Participants

4

Reactant 1

HCID 556016n-Methyl-3-nitropyridin-4-amine

Product 1

HCID 9104124-N-methylpyridine-3,4-diamineYield 80%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

150 mg of platinum oxide was added to 10 ml of a solution of 3-nitro-4-methylaminopyridine (1.5 g) in ethanol. The mixture was stirred under a hydrogen atmosphere at room temperature for 7.5 hours. Platinum oxide was removed by filtration, and the filtrate was concentrated. Thus, 962 mg (yield: 80%) of the intended product was obtained as brown crude crystals.

Workup

  1. customPlatinum oxide was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-af9e2d59fb474d53bf03f42d73f61d2d
Source dataset
uspto-grants-1994_12
Patent number
US05371086

Reaction notes

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