HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Amino-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 4-Chloro-3-nitropyridine | HCID 2735781 | — |
| Product | 4-Amino-3-nitropyridine | HCID 548803 | 59.3% |
Reaction Steps
Five grams (31.5 mmol) of 3-nitro-4-chloropyridine was mixed with 26 g of ammonium acetate, and the mixture was heated at 130°-140° C. for 3 hours. The mixture was allowed to cool, and then adjusted to pH 10 with concentrated aqueous ammonia. The precipitated powder was collected by filtration to obtain 2.6 g of the intended product (yield: 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05371086 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-54fb4af1f66b4c588175f8beca76da9b |
| Source note | uspto-grants-1994_12 |