Water → HCID 18953962, compound

HRID 1491673Notes

Reaction equation

HRID 1491673 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH2:13][CH2:14][CH2:15][OH:16])[O:11][CH:12]=2)=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18].O>N1C=CC=CC=1>[C:17]([O:16][CH2:15][CH2:14][CH2:13][C:10]1[O:11][CH:12]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[N:9]=1)(=[O:19])[CH3:18]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 9837611HCID 9837611, compound

Product 1

HCID 18953962HCID 18953962, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution 3-[4-(4-chlorophenyl)-2-oxazolyl]propanol (0.5 g) in pyridine (5 ml) was added acetic anhydride (1.0 ml), followed by stirring for 30 minutes at 50° to 60° C. The reaction mixture was poured into water. The precipitated crystals were collected by filtration to obtain 3-[4-(4-chlorophenyl)-2-oxazolyl]propyl acetate (0.535 g, 91%). Recrystallization from ether-hexane gave colorless prism crystals of mp 37°-37.5° C.

Workup

  1. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-a8fd7c204471447fa9adcf72240e9cfb
Source dataset
uspto-grants-1994_12
Patent number
US05371098

Reaction notes

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