反应详情

To a solution of 3-[4-(4-chlorophenyl)-2-oxazolyl]-propanol (0.5 g) in pyridine (2 ml) was added benzoyl chloride (0.29 ml), followed by stirring for an hour at room temperature. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed succesively with an aqueous sodium hydrogen carbonate solution, 2N-HCl and water, dried over MgSO4 and distilled to remove the solvent. The precipitated crystals were collected by filtration to give 3-[4-(4-chlorophenyl)-2-oxazolyl]propyl benzoate (0.687 g, 96%). Recrystallization from ether-hexane gave colorless prism crystals of mp 47°-47.5° C.

1. extractionextracted with ethyl acetate
2. washThe ethyl acetate layer was washed succesively with an aqueous sodium hydrogen carbonate solution, 2N-HCl and water
3. dry with materialdried over MgSO4
4. distillationdistilled
5. customto remove the solvent
6. filtrationThe precipitated crystals were collected by filtration