(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15337566, compound

HRID 1491704Notes

Reaction equation

HRID 1491704 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[NH:15]1[CH:19]=[CH:18][N:17]=[N:16]1.FC1C=C(F)C=CC=1[C@]1([C@H](N2N=CC=N2)C)CO1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:15]2[CH:19]=[CH:18][N:17]=[N:16]2)[CH3:13])[CH2:11][O:10]1

Participants

4

Reactant 3

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 15337568HCID 15337568, compoundHCID 178418936HCID 178418936, compound

Product 1

HCID 15337566HCID 15337566, compound

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl] ethanol (497 mg) and 1H-1,2,3-triazole, (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(2H-1,2,3-triazole-2-yl)-ethyl]oxirane (150 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(1H-1,2,3-triazol-1-yl)ethyl]oxirane (204 mg) were obtained by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-2953805aef7d4fcc995a0e095a7e98bf
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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