HCID 10040372, compound → HCID 10383348, compound

HRID 1491724Notes

Reaction equation

HRID 1491724 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[CH3:6][C@@H:7]1[O:9][C@@:8]1([CH2:21][N:22]1[CH:26]=[N:25][CH:24]=[N:23]1)[C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1>>[N:1]1[N:2]([C@H:7]([CH3:6])[C@:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:18])[F:19])=[CH:12][CH:11]=2)([OH:9])[CH2:21][N:22]2[CH:26]=[N:25][CH:24]=[N:23]2)[N:3]=[CH:4][CH:5]=1.[N:1]1([C@H:7]([CH3:6])[C@:8]([C:10]2[CH:11]=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:15]=2)([OH:9])[CH2:21][N:22]2[CH:26]=[N:25][CH:24]=[N:23]2)[CH:5]=[CH:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 10040372HCID 10040372, compoundHCID 178418936HCID 178418936, compound

Product 2

HCID 10383348HCID 10383348, compoundHCID 10429087HCID 10429087, compound

Procedure

Using 1H-1,2,3-triazole and (2R,3S)-3-methyl-2-[(1H-1,2,4-triazol-1-yl) methyl]-2-(4-trifluoromethoxylphenyl)oxirane, substantially the same reaction as in Example 30 was conducted to give Compound 40 as colorless prisms and Compound 41 as colorless needles.

Workup

  1. customsubstantially the same reaction as in Example 30

Sources & evidence

ORD record
ord-e44d66066e3441f7bd7bc4b85a504e9b
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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