1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole → (2R,3R)-2-(2-fluorophenyl)-3-(triazol-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol

HRID 1491726Notes

Reaction equation

HRID 1491726 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C@@:13]1([CH2:17][N:18]2[CH:22]=[N:21][CH:20]=[N:19]2)[C@H:15]([CH3:16])[O:14]1>>[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C@:13]([OH:14])([C@H:15]([N:1]1[CH:5]=[CH:4][N:3]=[N:2]1)[CH3:16])[CH2:17][N:18]1[CH:22]=[N:21][CH:20]=[N:19]1

Participants

3

Reactant 2

HCID 104439761-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazoleHCID 178418936HCID 178418936, compound

Product 1

HCID 462673(2R,3R)-2-(2-fluorophenyl)-3-(triazol-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol

Procedure

Using 1H-1,2,3-triazole and (2R,3S)-2-(2-fluorophenyl)-3-methyl-2-[(1H-1,2, 4-triazol-1-yl)methyl]oxirane, Compound 44 and Compound 45 were obtained by the same way as in Example 30.

Sources & evidence

ORD record
ord-22299852849947e184022abf5d105b65
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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