HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane | HCID 18657628 | — |
| Product | (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol | HCID 54133618 | 77.4% |
Reaction Steps
Using 1H-1,2,4-triazole (74 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9-(9H)-purinyl]ethyl]oxirane (183 mg), Compound 47 (171 mg) was obtained as colorless prisms by the same was as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05371100 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-bda2d0b6439d476095186039788e08a8 |
| Source note | uspto-grants-1994_12 |