1H-1,2,4-Triazole → HCID 54169401, compound

HRID 1491728Notes

Reaction equation

HRID 1491728 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[C@:14]1([C@H:17]([N:19]2[CH:27]=[N:26][C:25]3[C:20]2=[N:21][CH:22]=[N:23][C:24]=3[CH3:28])[CH3:18])[CH2:16][O:15]1>>[F:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[C@:14]([OH:15])([C@H:17]([N:19]1[CH:27]=[N:26][C:25]2[C:20]1=[N:21][CH:22]=[N:23][C:24]=2[CH3:28])[CH3:18])[CH2:16][N:1]1[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 57109516HCID 57109516, compound

Product 1

HCID 54169401HCID 54169401, compoundYield 16.7%

Procedure

Using 1H-1,2,4-triazole (167 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methyl-9(9H)-purinyl]ethyl] oxirane (388 mg), Compound 48 (79 mg) was obtained as colorless prisms by the same way as in Example 1.

Sources & evidence

ORD record
ord-c5b4b58dd0d040d589b6f7a2e56d445b
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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