(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

Participants

Role	Name	HCID	Charge
Reactant	(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol	HCID 10631861	—
Reactant	4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one	HCID 10702483	—
Product	2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone	HCID 10618567	30%

Reaction Steps

In the same manner as in Reference Example 5, starting from 1.35 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 963 mg of 4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone, 583 mg of 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone was obtained as colorless needles.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05371101
Source dataset	uspto-grants-1994_12
ORD ID	ord-f2ea12e2071a436fa2f8cdf923ce565b
Source note	uspto-grants-1994_12