4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone → 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

Participants

Role	Name	HCID	Charge
Reactant	4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone	HCID 10585484	—
Reactant	(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol	HCID 10631861	—
Product	2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone	HCID 10597727	37.5%

Reaction Steps

In the same manner as in Reference Example 5, starting from 1.64 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.87 g of 4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone (1.26 g) was obtained as colorless crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05371101
Source dataset	uspto-grants-1994_12
ORD ID	ord-4c30b56cbaa04afca813e10631ff5e0b
Source note	uspto-grants-1994_12