HCID 3727569, compound → HCID 15285767, compound

HRID 1491760Notes

Reaction equation

HRID 1491760 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:30])([F:29])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH:27]=[N:26][NH:25][C:24]1=[O:28]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:25]1[C:24](=[O:28])[N:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:16]([F:15])([F:30])[F:29])[CH:27]=[N:26]1)[CH3:13]

Participants

3

Reactant 2

HCID 3727569HCID 3727569, compoundHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 15285767HCID 15285767, compoundYield 20.3%

Procedure

In the same manner as in Reference Example 5, starting from 1.0 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.1 g of 4-(2-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(2-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone (0.4 g) was obtained as a colorless powder.

Sources & evidence

ORD record
ord-c1fd06f5b8294123aa93b75c8659df4c
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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