(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15285769, compound

HRID 1491761Notes

Reaction equation

HRID 1491761 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[CH:15]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[N:28][NH:27][C:26]2=[O:30])=[CH:21][CH:20]=1)([CH3:17])[CH3:16]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:27]1[C:26](=[O:30])[N:25]([C:22]2[CH:21]=[CH:20][C:19]([O:18][CH:15]([CH3:17])[CH3:16])=[CH:24][CH:23]=2)[CH:29]=[N:28]1)[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 19373640HCID 19373640, compound

Product 1

HCID 15285769HCID 15285769, compoundYield 48.8%

Procedure

In the same manner as in Reference Example 5, starting from 1.43 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.94 g of 4-(4-isopropoxyphenyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-isopropoxyphenyl)-3(2H,4H)-1,2,4-triazolone (0.84 g) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-1da277014a1f4843b55959b2b321e179
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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