(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 18657633, compound

HRID 1491762Notes

Reaction equation

HRID 1491762 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[CH3:15][CH:16]([CH3:25])[CH2:17][CH2:18][N:19]1[CH:23]=[N:22][NH:21][C:20]1=[O:24]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:21]1[C:20](=[O:24])[N:19]([CH2:18][CH2:17][CH:16]([CH3:25])[CH3:15])[CH:23]=[N:22]1)[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 19373684HCID 19373684, compound

Product 1

HCID 18657633HCID 18657633, compoundYield 49.4%

Procedure

In the same manner as in Reference Example 5, starting from 1.38 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.21 g of 4-(3-methylbutyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-Difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(3-methylbutyl)-3(2H,4H)-1,2,4-triazolone (1.15 g) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-690b7984c2554f2394731b546a3649bc
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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