HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol | HCID 10631861 | — |
| Reactant | 4-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one | HCID 19689796 | — |
| Product | 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone | HCID 11595984 | 18.5% |
Reaction Steps
In the same manner as in Reference Example 5, starting from 0.66 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.65 g of 4-(4-chlorophenyl)-3(2H,4H)-1,2,4-triazolone, 0.23 g of 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone was obtained as a colorless viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05371101 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-f9cd27f2bbea4d58a86682e84c1d3881 |
| Source note | uspto-grants-1994_12 |