(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15285781, compound

HRID 1491773Notes

Reaction equation

HRID 1491773 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:32])([F:31])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[CH:28][NH:27][C:26]2=[O:30])=[CH:21][CH:20]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:27]1[CH:28]=[CH:29][N:25]([C:22]2[CH:23]=[CH:24][C:19]([O:18][CH2:17][C:16]([F:31])([F:32])[F:15])=[CH:20][CH:21]=2)[C:26]1=[O:30])[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 19373665HCID 19373665, compound

Product 1

HCID 15285781HCID 15285781, compoundYield 25.1%

Procedure

In the same manner as in Reference Example 5, starting from 0.68 g of (1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.70 g of 1-[4-(2,2,2-trifluoroethoxy)phenyl]-2(1H,3H)-imidazolone, 0.30 g of 1-[-(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1methylpropyl]-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2(1H,3H)-imidazolone was obtained as colorless needles.

Sources & evidence

ORD record
ord-bc44282ec65440e891f8641b503573d5
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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