(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 10504121, compound

HRID 1491780Notes

Reaction equation

HRID 1491780 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:33])([O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[C:31](=[O:32])[NH:30][CH:29]=[N:28]2)=[CH:23][CH:22]=1)[CH:17]([F:19])[F:18]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:30]1[CH:29]=[N:28][N:27]([C:24]2[CH:25]=[CH:26][C:21]([O:20][C:16]([F:33])([F:15])[CH:17]([F:19])[F:18])=[CH:22][CH:23]=2)[C:31]1=[O:32])[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 135536680HCID 135536680, compound

Product 1

HCID 10504121HCID 10504121, compoundYield 57%

Procedure

In the same manner as in Reference Example 5, starting from 1.15 g of (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.27 g of 2-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3(2H,4H)-1,2,4-triazolone, 1.20 g of 4-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-2-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3(2H,4H)-1,2,4-triazolone was obtained as colorless needles.

Sources & evidence

ORD record
ord-e7aae3a24dae46c5b283a1c86ab0b750
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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