N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

Participants

Reaction Steps

This urea (37.5 g) was dissolved in a mixture of 560 mL of methanol and 280 ml of water, and 300 ml of 0.48M hydrochloric acid was added thereto and the resulting mixture was stirred for three days at room temperature. The reaction solution was concentrated under reduced pressure. The crystals thus separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone as a colorless powder.

Provenance & Evidence