Epichlorohydrin → HCID 20093598, compound

HRID 1491801Notes

Reaction equation

HRID 1491801 reaction equation
[S:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[OH:11].[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl>>[O:16]1[CH2:15][CH:14]1[CH2:12][O:11][CH:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[S:1]1

Participants

3

Reactant 2

HCID 7835EpichlorohydrinHCID 23450714HCID 23450714, compound

Product 1

HCID 20093598HCID 20093598, compoundYield 65,000%

Procedure

The procedure of Step A of Example 1 is followed, starting from 1.72 g (10.34 mmol) of thiochromanol and 7.653 g (82.72 mmol) of epichlorohydrin. 1.5 g (6,721 mmol) of 2,3-epoxypropoxythiochroman are obtained.

Sources & evidence

ORD record
ord-a0f66dc05f554d8ba80483f78a044d15
Source dataset
uspto-grants-1994_12
Patent number
US05371103

Reaction notes

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